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ASBMR Webinar Series: Bench to Bedside and Back Again: Discontinuing Denosumab
Join Michelle McDonald, Ph.D. and Bente Langdahl, M.D., as they present a basic and clinical perspective on the topic of discontinuing denosumab.

Basic Perspective
Michelle McDonald, Ph.D, will present data from a pre-clinical study modelling Desnoumab withdrawal revealing rapid rises in serum TRAP levels above control levels precedes bone loss. She will also present data from a pre-clinical study showing early intervention with zoledronate in multiple doses is superior in preventing serum TRAP rise and bone loss following Desnoumab withdrawal. Lastly, Dr. McDonald will present intravital imaging studies, which reveal osteoclasts undergo cycles of fission and fusion (recycling), which is elevated during Denosumab withdrawal.

Clinical Perspective
Bente Langdahl, M.D., will present data from the ZOLARMAB study investigating different zoledronate regimens after denosumab discontinuation as well as other clinical intervention and observational trials adding information about how best to manage denosumab discontinuation. She will also discuss the recommendations by the ECTS position statement on denosumab discontinuation.

As a result of this webinar participants will be able to:
1. Demonstrate that a rapid rise in osteoclast activity drives bone loss following Denosumab withdrawal
2. Demonstrate that sequential multiple dose Bisphosphonate therapy may prevent Denosumab withdrawal induced bone loss
3. Outline how the novel concept of osteoclast recycling may provide the mechanism behind bone loss following Desnoumab withdrawal.
4. Demonstrate the rapid increase in p-CTX and bone loss after discontinuation of denosumab in patients with osteoporosis after long-term treatment
5. Demonstrate that subsequent treatment with bisphosphonate may ameliorate the rebound activation of bone resorption and bone loss to some extend
6. Outline how discontinuation of denosumab can be managed in the clinic.

Jun 16, 2021 02:00 PM in Eastern Time (US and Canada)

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